Nickelodeon Kart Racers 2: Grand Prix features a selection of 30 playable racers, consisting of characters from 12 different Nicktoons and real-life actress JoJo Siwa. Each character has different gameplay statistics such as top speed and handling, which can be further altered by customizing their kart with different unlockable vehicle parts. There are also 70 non-playable "pit crew" characters based on these shows, made up of 20 "chiefs" and 50 "crew", with players able to equip one chief and two crew before each race. Chief characters will give the player an additional ability they can activate at any time during the race, such as a sudden speed boost or temporary shield; each use requires players to first fill a slime meter by driving through slime or collecting slime tokens on the track.